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UID:1220@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260810T140000
DTEND;TZID=Asia/Jerusalem:20260810T150000
DTSTAMP:20260727T081601Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%93%d7%a8-%d7%99%d7%a2%d7%9c-%d7%93%d7%95%d7%93
 /
SUMMARY:סמינר אורח: ד"ר יעל דוד
DESCRIPTION:Metabolism Meets Epigenetics: Chemical Biology in Translational
  Discovery\n ** Lecture will be given in English**\nAbstract:\nThe epigen
 etic regulation of DNA-templated processes plays a fundamental role in sha
 ping cell identity and fate. Disruption of these regulatory networks contr
 ibutes to numerous diseases\, including cancer\, viral infection\, neurona
 l function and immune dysfunction. Many of these pathologies are accompani
 ed\nby profound alterations in genome organization\, including the formati
 on of non-canonical chromatin structures. Our work has uncovered the epige
 netic regulation of several such structures\, including micronuclei (Natur
 e\, 2023)\, extracellular vesicle-associated chromatin (Nature Cancer\, 20
 24)\, and the\nchromatinized genome of Hepatitis B virus (HBV) (Cell\, 202
 5). By investigating the molecular mechanisms underlying these processes\,
  we identified cellular metabolism as a major regulator of chromatin funct
 ion. We found that intrinsic metabolic programs\, as well as environmental
  influences such\nas nutrition and diabetes\, directly reshape the chromat
 in landscape through chemical modifications \, thereby altering gene expre
 ssion and cell fate (Nature Communications\, 2019\; Nature Communications\
 , 2020 .)In this talk\, I will present our latest discoveries defining thi
 s metabolism-epigenetics axis and\ndiscuss how metabolic stress reprograms
  chromatin to regulate T cell function. I will also highlight how these me
 chanistic insights are being translated into the development of a new gene
 ration of CAR T cells with enhanced therapeutic potential. Together\, thes
 e studies illustrate how fundamental discoveries in\nchemical biology and 
 epigenetics can reveal unexpected mechanisms of disease and inspire innova
 tive therapeutic strategies.
CATEGORIES:סמינרים
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