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UID:1162@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260506T140000
DTEND;TZID=Asia/Jerusalem:20260506T150000
DTSTAMP:20260426T065547Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%93%d7%a8-%d7%9c%d7%99%d7%90%d7%95%d7%a8-%d7%9c
 %d7%95%d7%91%d7%9c/
SUMMARY:סמינר אורח: ד"ר ליאור לובל
DESCRIPTION:Diet-Microbe-Host Interactions: From Molecules to Medicine\n *
 * Lecture will be given in English**\nAbstract:\nWhat we eat shapes who we
  are\, not just through calories and nutrients\, but through the trillions
  of microorganisms that inhabit our gut. The intestinal microbiome acts as
  a metabolic intermediary\, transforming dietary inputs into a diverse rep
 ertoire of bioactive compounds that profoundly influence host physiology. 
 Specific dietary components can be leveraged\, or inadvertently exploited\
 , to reprogram gut microbial activity and\, consequently\, alter host phen
 otype in health and disease.\nWork from our lab provided mechanistic evide
 nce demonstrating that sulfur amino acid intake drives the production of g
 ut-derived uremic toxins\, establishing a diet–microbiome axis as a caus
 al driver of chronic kidney disease progression (Lobel et al.\, Science\, 
 2020). Building on this framework\, ongoing studies in our lab examine how
  dietary fiber reshapes microbial metabolic activity in both mouse models 
 and human cohorts\, and how dietary nitrate engages distinct microbial enz
 ymatic pathways to exert systemic effects in mice.\nA final\, striking cli
 nical observation brings these themes into oncology: consumption of ultra-
 processed foods is associated with altered responses to immune checkpoint 
 immunotherapy in melanoma patients\, raising the possibility that diet\, a
 cting through the microbiome\, can determine whether a patient responds to
  cancer treatment.\nTogether\, these findings argue that diet is not merel
 y a lifestyle variable but a tractable biological lever for modulating mic
 robiome function and\, through it\, a surprisingly broad range of host out
 comes\, from metabolic disease to cancer immunology.
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CATEGORIES:סמינרים
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TZID:Asia/Jerusalem
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DTSTART:20260327T030000
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