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UID:1162@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260513T140000
DTEND;TZID=Asia/Jerusalem:20260513T150000
DTSTAMP:20260506T053830Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%93%d7%a8-%d7%9c%d7%99%d7%90%d7%95%d7%a8-%d7%9c
 %d7%95%d7%91%d7%9c/
SUMMARY:סמינר אורח: פרופ' ליהי אדלר אברמוביץ
DESCRIPTION:Engineered Supramolecular Nanostructures for Tissue Regeneratio
 n\n ** Lecture will be given in English**\nAbstract:\nAdvances in regener
 ative medicine require materials that enable precise control over nanoscal
 e organization\, mechanical properties\, and biological function. Our work
  focuses on bioinspired supramolecular scaffolds based on short aromatic p
 eptides that undergo solvent-regulated self-assembly and polymorphic phase
  transitions. This approach allows fine-tuning of crystalline structure\, 
 stiffness\, and bioactivity.\nCo-assembly of complementary dipeptides yiel
 ds exceptionally rigid hydrogels that promote cell mechanotransduction and
  osteogenic differentiation. Integration with biopolymers\, such as hyalur
 onic acid and gelatin\, yields injectable\, 3D-printable composite hydroge
 ls with thixotropic behavior and enhanced calcium mineralization\, resulti
 ng in significant bone regeneration in vivo. To expand their functionality
 \, we fabricate patient-specific\, bioactive titanium implants via additiv
 e manufacturing and incorporate bioactive scaffolds to enhance their perfo
 rmance in bone rehabilitation following tumor resection .\nIn addition\, w
 e design conductive peptide-MXene hybrid hydrogels that function as piezor
 esistive sensors for real-time tissue monitoring and electrical stimulatio
 n. Furthermore\, we developed an autologous electrospun polymer-peptide sk
 in equivalent for the treatment of severe burn injuries\, demonstrating ac
 celerated wound closure and a reduction of T₅₀ from 12 to 4 days.\nTog
 ether\, these studies establish a modular platform that integrates mechani
 cal tunability\, printability\, and sensing capabilities\, enabling the de
 sign of multifunctional biomaterials and hybrid bioelectronic interfaces. 
 This supramolecular strategy offers a versatile route toward personalized 
 regenerative systems with strong translational potential across both soft 
 and hard tissue repair .\nReferences :\n1. Cohen-Gerassi\, D. et al. Adv. 
 Funct. Mater. 2025\, 2501745.\n2. Netti\, F. et al. Adv. Healthcare Mater.
  2025\, e01729.\n3. Dan\, Y. et al. Nat. Commun. 2025\, 16\, 6106.\n4. Coh
 en-Gerassi\, D. et al. Adv. Healthcare Mater. 2024\, 2303632.\n5. Halperin
 -Sternfeld\, M. et al. J. Clin. Periodontol. 2023\, 50\, 200–219.
CATEGORIES:סמינרים
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