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TZID:Asia/Jerusalem
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UID:1282@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20261111T140000
DTEND;TZID=Asia/Jerusalem:20261111T150000
DTSTAMP:20261028T133138Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%93%d7%a8-%d7%a2%d7%a8%d7%9f-%d7%91%d7%9c%d7%9b
 %d7%a8/
SUMMARY:סמינר אורח: ד"ר ערן בלכר
DESCRIPTION:Age-dependent gut barrier failure amplifies stroke injury via a
  microbiota-lipid axis\nAbstract:  ** Lecture will be given in English**\
 nAging is the strongest predictor of poor recovery after ischemic stroke\,
  yet the mechanisms underlying this vulnerability remain incompletely unde
 rstood and are often considered primarily within the brain. Here\, we inve
 stigated whether age-related changes in the intestinal barrier contribute 
 to worse stroke outcomes. Analysis of human colon tissue revealed substant
 ial age-associated remodeling of the intestinal environment\, including im
 paired barrier-supporting structures and increased inflammation. We then e
 xamined the response to experimental stroke in young and aged mice. Compar
 ed with young animals\, aged mice developed more persistent intestinal dam
 age\, greater barrier leakage\, and increased spread of microbial products
  and bacteria beyond the gut. These changes were accompanied by widespread
  and prolonged inflammatory responses across the intestine\, circulation\,
  and brain. We further identified age-dependent alterations in the gut mic
 robiome and its metabolites\, suggesting that aging disrupts protective co
 mmunication between the gut and peripheral organs after stroke. Restoring 
 a selected microbiome-derived metabolite improved intestinal barrier integ
 rity and reduced brain injury in aged mice. Together\, our findings identi
 fy the aging gut as an important regulator of systemic inflammation and ne
 urological damage after stroke and highlight the gut-brain axis as a poten
 tial therapeutic target for improving recovery in older individuals.
CATEGORIES:סמינרים
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