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UID:1149@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260218T140000
DTEND;TZID=Asia/Jerusalem:20260218T150000
DTSTAMP:20260209T135633Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%a4%d7%a8%d7%95%d7%a4-%d7%91%d7%95%d7%a2%d7%96-
 %d7%91%d7%a8%d7%a7/
SUMMARY:סמינר אורח: פרופ' בועז ברק
DESCRIPTION:Myelination beyond development: glial contributions to brain dy
 sfunction\n ** Lecture will be given in English**\nAbstract:\nMyelination
  is a fundamental biological process that enables efficient signal transmi
 ssion in the nervous system and supports coordinated brain activity and be
 havior. Accumulating evidence suggests that myelination is dynamically reg
 ulated and vulnerable across neurodevelopmental disorders. In this talk\, 
 I will present work from our lab examining how genetic perturbations linke
 d to Williams syndrome and autism spectrum disorders disrupt myelinating g
 lial cells and white matter integrity\, with consequences for neural funct
 ion and behavior. Using cell type-specific genetic mouse models\, human iP
 SC-derived glial cells\, and multi-scale molecular\, cellular\, and physio
 logical approaches\, we uncover unexpected roles for disease-associated ge
 nes in oligodendrocytes and their precursors. Our findings demonstrate tha
 t altered gene function in myelinating cells can impair axonal conductivit
 y\, network synchronization\, and behavior\, while targeted modulation of 
 myelination can partially rescue these deficits. Together\, these studies 
 highlight oligodendrocytes as active contributors to neurodevelopmental pa
 thology and identify myelination as a potential therapeutic entry point ac
 ross disorders with distinct genetic origins.
CATEGORIES:סמינרים
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