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UID:1154@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260311T140000
DTEND;TZID=Asia/Jerusalem:20260311T150000
DTSTAMP:20260225T130235Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%90%d7%95%d7%a8%d7%97-%d7%a4%d7%a8%d7%95%d7%a4-%d7%93%d7%9f-%d7%a4%d7%90
 %d7%a8/
SUMMARY:סמינר אורח: פרופ' דן פאר
DESCRIPTION:The RNA Revolution: from Vaccines to Therapeutic Genome Editing
 \n ** Lecture will be given in English**\nAbstract:\nObjectives: Modulati
 ng gene expression that can lead to cell death in the case of tumors or to
  change of expression of desired proteins for protein replacement therapy 
 or for vaccines or editing of cells for knockout or knockin of genes is a 
 major challenge and an unmet medical need.\nMethods: We have developed sev
 eral strategies to target unique cell surface receptors\, as well as a ver
 y large library of ionizible lipids with two special features: highly immu
 nogenic or less immunogenic (that can be used for repeated doses). In addi
 tion\, we developed novel mRNA sequences with more potent immunogenicity t
 hat can be utilized against bacterial infection.\nResults: In this talk\, 
 I will share several examples ranging from new therapeutic targets identif
 ied for cancer (e.g. CKAP5) to the first bacterial mRNA vaccine and will a
 lso share some data on gene editing for cancer therapeutics.\nConclusions:
  Cell specific delivery of RNA payloads is feasible and represent the next
  generation milestone in personalized medicine.
ATTACH;FMTTYPE=image/jpeg:https://biotech.technion.ac.il/wp-content/upload
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CATEGORIES:סמינרים
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