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UID:1178@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260629T140000
DTEND;TZID=Asia/Jerusalem:20260629T150000
DTSTAMP:20260519T121044Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%a1%d7%99%d7%95%d7%9d-%d7%93%d7%95%d7%a7%d7%98%d7%95%d7%a8%d7%98-%d7%92%
 d7%99-%d7%a6%d7%9f-%d7%9e%d7%94%d7%9e%d7%a2%d7%91%d7%93%d7%94-%d7%a9%d7%9c
 -%d7%a4%d7%a8/
SUMMARY:סמינר סיום דוקטורט: גי צ'ן\, מהמעבדה ש
 ל פרופ' דגנית דנינו ופרופ' הרולד קורק
DESCRIPTION:Research Topic: Developing starch nanoparticles from waxy rice 
 starch by advanced green chemistry techniques for bioactive compound encap
 sulation\n\n\nAbstract: ** Lecture will be given in English**\nStarch nano
 particles (SNP) can be used as biodegradable materials for the encapsulati
 on and delivery of bioactive compounds. However\, their sustainable produc
 tion remains a significant challenge\, as traditional methods are hindered
  by low yields\, poor scalability\, and use of high concentrations of acid
 . In this study\, an enzymatic method was developed to produce SNP from wa
 xy rice starch\, offering high efficiency and potential for large-scale pr
 oduction\, suitable for encapsulation and protection of bioactive compound
 s.\nThe research includes a detailed characterization waxy rice starch fro
 m eight Japonica waxy rice cultivars\, linking amylopectin fine structure 
 to functional properties. Using this insight\, starch from three cultivars
  with different structures were selectively modified with α-amylases from
  different sources (porcine pancreas\, Bacillus amyloliquefaciens\, and As
 pergillus oryzae)\, demonstrating how α-amylase from various sources diff
 er in their action on waxy rice starch with different structures.\nAn effi
 cient SNP synthesis method was established using α-amylase pretreatment\,
  pullulanase debranching\, and nanoprecipitation\, producing compact SNP a
 s revealed by Cryo-EM. To overcome the hydrophobicity limitation for encap
 sulating hydrophobic compounds\, SNP were modified with citric acid and su
 ccessfully loaded with hesperetin\, a hydrophobic flavonoid. In vitro dige
 stion showed that this encapsulation significantly increased the retention
  of antioxidant and anti-diabetic activity of hesperetin. Finally\, hesper
 etin-loaded SNP were incorporated into starch-based edible films\, which e
 xtended blueberry shelf-life by increasing the barrier properties of starc
 h-based films.\nOverall\, by integrating insights on waxy rice starch amyl
 opectin structure\, source-specific enzyme selection\, and hydrophobic mod
 ification\, this work offers a route to produce new bioactive-loaded SNP\,
  with potential for further applications.
CATEGORIES:סמינרים
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