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TZID:Asia/Jerusalem
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UID:1178@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260629T140000
DTEND;TZID=Asia/Jerusalem:20260629T150000
DTSTAMP:20260617T125716Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%a1%d7%99%d7%95%d7%9d-%d7%93%d7%95%d7%a7%d7%98%d7%95%d7%a8%d7%98-%d7%92%
 d7%99-%d7%a6%d7%9f-%d7%9e%d7%94%d7%9e%d7%a2%d7%91%d7%93%d7%94-%d7%a9%d7%9c
 -%d7%a4%d7%a8/
SUMMARY:סמינר סיום דוקטורט: גי צ'ן\, מהמעבדה ש
 ל פרופ' דגנית דנינו ופרופ' הרולד קורק
DESCRIPTION:Developing starch nanoparticles from waxy rice starch by advanc
 ed green chemistry techniques for bioactive compound encapsulation\nAbstra
 ct: ** Lecture will be given in English**\nStarch nanoparticles (SNP) can 
 be used as biodegradable materials for the encapsulation and delivery of b
 ioactive compounds. However\, their sustainable production remains a signi
 ficant challenge\, as traditional methods are hindered by low yields\, poo
 r scalability\, and use of high concentrations of acid. In this study\, an
  enzymatic method was developed to produce SNP from waxy rice starch\, off
 ering high efficiency and potential for large-scale production\, suitable 
 for encapsulation and protection of bioactive compounds.\nThe research inc
 ludes a detailed characterization waxy rice starch from eight Japonica wax
 y rice cultivars\, linking amylopectin fine structure to functional proper
 ties. Using this insight\, starch from three cultivars with different stru
 ctures were selectively modified with α-amylases from different sources (
 porcine pancreas\, Bacillus amyloliquefaciens\, and Aspergillus oryzae)\, 
 demonstrating how α-amylase from various sources differ in their action o
 n waxy rice starch with different structures.\nAn efficient SNP synthesis 
 method was established using α-amylase pretreatment\, pullulanase debranc
 hing\, and nanoprecipitation\, producing compact SNP as revealed by Cryo-E
 M. To overcome the hydrophobicity limitation for encapsulating hydrophobic
  compounds\, SNP were modified with citric acid and successfully loaded wi
 th hesperetin\, a hydrophobic flavonoid. In vitro digestion showed that th
 is encapsulation significantly increased the retention of antioxidant and 
 anti-diabetic activity of hesperetin. Finally\, hesperetin-loaded SNP were
  incorporated into starch-based edible films\, which extended blueberry sh
 elf-life by increasing the barrier properties of starch-based films.\nOver
 all\, by integrating insights on waxy rice starch amylopectin structure\, 
 source-specific enzyme selection\, and hydrophobic modification\, this wor
 k offers a route to produce new bioactive-loaded SNP\, with potential for 
 further applications.
CATEGORIES:סמינרים
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TZID:Asia/Jerusalem
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