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TZID:Asia/Jerusalem
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UID:1175@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260603T140000
DTEND;TZID=Asia/Jerusalem:20260603T150000
DTSTAMP:20260519T120732Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%a1%d7%99%d7%95%d7%9d-%d7%93%d7%95%d7%a7%d7%98%d7%95%d7%a8%d7%98-%d7%a4%
 d7%90%d7%99%d7%92%d7%95%d7%a0%d7%92-%d7%99%d7%95-%d7%9e%d7%94%d7%9e%d7%a2%
 d7%91%d7%93/
SUMMARY:סמינר סיום דוקטורט: פאיג'ונג יו\, מהמע
 בדה של פרופ' אורי לזמס ופרופ"ח יגאל אכמון
DESCRIPTION:Research Topic: Quality evolution\, maturation\, microbial succ
 ession and digestive fate of Citri Reticulatae Pericarpium (CRP)\nAbstract
 : ** Lecture will be given in English**\nCitri Reticulatae Pericarpium (CR
 P)\, particularly the pericarp of Citrus reticulata ‘Chachi’ (GCP)\, i
 s widely used in China as food and herbal medicine\, with quality improvin
 g during aging. However\, the dynamic changes and the underlying microbial
  shifts during storage remain poorly understood\, particularly with respec
 t to bioactivity and digestibility. This study investigated how environmen
 tal factors (storage conditions\, aging time\, and origin) influence quali
 ty\, digestive fate\, microbial succession\, and metabolite transformation
 \, as well as microbiome–metabolome interactions involved in GCP quality
  variation.\nWe first evaluated the effects of storage conditions (tempera
 ture and humidity) and aging time on aged GCP. Real-time monitoring of mic
 robial respiration (O2\, CO2\, and CH4) and volatile organic compounds (VO
 Cs)\, and flavonoid determinations suggested active microbial metabolism a
 s a potential key driver of quality. Multi-omics analyses revealed that mi
 crobial genera such as Aspergillus\, Cladosporium\, Xeromyces\, and Pseudo
 monas were significantly associated with flavonoids\, particularly hesperi
 din and didymin. Functional prediction further indicated microbial pathway
 s involved in metabolite transformations. The functional implications of a
 ging on consumer exposure were further assessed using in vitro digestion s
 imulations\, showing that the bioaccessibility of hesperidin in GCP decoct
 ions remained relatively stable (~30–50%) regardless of aging time or co
 nsumer’s sex. In a subsequent investigation focusing on early-stage agin
 g\, freshly dried citrus peels were monitored over the course of 12 months
 . Color development was accompanied by varying levels of flavonoids\, vola
 tile and non-volatile metabolites. The initial microbial succession was ch
 aracterized by the dominance of genera such as Methylobacterium\, Sphingom
 onas\, Cladosporium\, and Zasmidium. Collectively\, our results suggest th
 at the first year is critical for the quality evolution of GCP. Overall\, 
 these findings highlight the important role of microbial communities in me
 diating bioactive compound transformations\, providing a theoretical basis
  for optimizing storage\, standardizing the aging process\, and enhancing 
 the quality of GCP.
CATEGORIES:סמינרים
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DTSTART:20260327T030000
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