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TZID:Asia/Jerusalem
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UID:1156@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260413T140000
DTEND;TZID=Asia/Jerusalem:20260413T143000
DTSTAMP:20260412T065042Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%a1%d7%99%d7%95%d7%9d-%d7%9e%d7%92%d7%99%d7%a1%d7%98%d7%a8-%d7%92%d7%9c%
 d7%99-%d7%9b%d7%94%d7%9f-%d7%92%d7%93%d7%95%d7%9c-%d7%9e%d7%94%d7%9e%d7%a2
 %d7%91%d7%93%d7%94/
SUMMARY:סמינר סיום מגיסטר: גלי כהן-גדול\, מהמע
 בדה של פרופ"ח בעז מזרחי
DESCRIPTION: Double layer and dual drug loaded microneedle patch for compr
 ehensive skin therapy\n ** Lecture will be given in English**\nAbstract:\
 nMicroneedle based drug delivery provides a minimally invasive strategy fo
 r localized and controlled transdermal administration of therapeutics\, ye
 t precise temporal control of multi drug release remains challenging in se
 ttings that demand both rapid and sustained pharmacological effects. This 
 study presents two microneedle platforms for controlled co delivery of bup
 ivacaine (local anesthetic) and ampicillin (antibiotic)\, exploiting the d
 istinct dissolution behaviors of hyaluronic acid and chitosan to program r
 elease kinetics. In the first design\, a double layered microneedle was fa
 bricated with hyaluronic acid-ampicillin confined to the needle tips for r
 apid dissolution\, and a chitosan–bupivacaine core and base to enable sl
 ower\, sustained release. In the second design\, chitosan–bupivacaine mi
 croneedles were coated with an outer hyaluronic acid–ampicillin layer to
  create a fast releasing shell around a sustained release interior. Both m
 icroneedle arrays showed uniform morphology and sufficient mechanical stre
 ngth for skin insertion. Spinning disk confocal microscopy confirmed discr
 ete spatial localization of the polymers in both systems: hyaluronic acid 
 restricted to the tips in the double layered microneedle and forming a dis
 tinct outer shell in the coated microneedle\, while chitosan remained with
 in the underlying needle matrix. In vitro release studies using Franz diff
 usion cells demonstrated rapid ampicillin liberation compared with a prolo
 nged bupivacaine release profile\, consistent with the designed dissolutio
 n hierarchy of hyaluronic acid and chitosan. These findings verify that du
 al drug delivery with differential temporal profiles can be achieved by in
 tegrating polymer specific dissolution kinetics with microneedle architect
 ure. Such platforms may be particularly valuable for clinical applications
  requiring immediate release such as antimicrobial protection combined wit
 h a more extended release such as the case for analgesia\, for example\, i
 n post surgical care and wound management.
CATEGORIES:סמינרים
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TZID:Asia/Jerusalem
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