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UID:1205@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20260722T143000
DTEND;TZID=Asia/Jerusalem:20260722T150000
DTSTAMP:20260715T132313Z
URL:https://biotech.technion.ac.il/events/%d7%a1%d7%9e%d7%99%d7%a0%d7%a8-%
 d7%a1%d7%99%d7%95%d7%9d-%d7%9e%d7%92%d7%99%d7%a1%d7%98%d7%a8-%d7%a6%d7%9c%
 d7%99%d7%9f-%d7%a7%d7%94-%d7%9e%d7%94%d7%9e%d7%a2%d7%91%d7%93%d7%94-%d7%a9
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SUMMARY:סמינר סיום מגיסטר: צ'לין קה\, מהמעבדה 
 של פרופ' דגנית ודנינו ופרופ' קה יין לאונג
DESCRIPTION:Research Topic: Horizontal gene transfer of antibiotic resistan
 ce in selected bacteria in Chinese frog farms\nAbstract: ** Lecture will b
 e given in English** (249 words)\nHorizontal gene transfer (HGT) enables b
 acteria to rapidly acquire new traits and to adapt to changing environment
 s. Identifying prominent HGT regions in bacterial genomes can reveal essen
 tial genetic mechanisms in microbial evolution and resistome development. 
 We used comparative genomics to identify putative HGT regions in the genom
 es of 109 antibiotic resistant bacteria isolated from intensive Chinese fr
 og farms in 2019 (old samples). These isolates included Escherichia coli\,
  Edwardsiella tarda\, and Citrobacter and Klebsiella species. We identifie
 d and defined 174 representative genomic islands (GIs) that were enriched 
 in antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs). 
 Integron-associated GIs were the major ARG hotspots (100% contained ARGs) 
 and carried a significantly greater ARG load than non-integron-associated 
 GIs (39% contained ARGs). These GIs were also detected in sediment samples
  collected in 2024 (new samples) from frog farms in a 10 km vicinity of th
 e old samples. These integron-associated GIs mediated the transfer of ARGs
  between different plasmids and between plasmids and the chromosome. Furth
 er analysis revealed that genomic islands such as GI38\, GI212\, and GI285
  were widely distributed across different biosamples\, habitats\, and cont
 inents. These results demonstrated that HGT\, especially integron-associat
 ed GIs can mediate the dissemination and persistence of ARGs across bacter
 ial hosts in intensive frog farms and other habitats. Therefore\, understa
 nding ARGs-MGEs-host relationships in resistomes can facilitate the develo
 pment of effective antibiotic resistance mitigation strategies and advance
  our knowledge of One Health dynamics.
CATEGORIES:סמינרים
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