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UID:898@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20191225T160000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124721Z
URL:https://biotech.technion.ac.il/events/cellulose-based-biomaterials-a-p
 lot-twist-2/
SUMMARY:Cellulose-based biomaterials: a plot twist
DESCRIPTION:In recent years\, chemical protocols in various academic\, clin
 ical\, and industrial studies around the world have begun to slowly shift 
 their norms toward finding safer ways for the production of novel materia
 ls and technologies. New directions rely on basing design concepts inspire
 d from nature-sourced polymers\, which are thought to hold great promise a
 s virtually inexhaustible source materials. The perfection of chemically m
 odifying these polymers is therefore relevant now more than ever\, with fa
 r-reaching and diverse applicative prospects. As a model biopolymer\, cell
 ulose has a rich history of industrial uses\, and is still incorporated in
  over 1200 patents annually. In an ocean of man-made synthetic polymers\, 
 one discovery stood out\, as the Cegelski group from Stanford University u
 nearthed the identity of the first-ever recorded naturally modified cellul
 ose. Secreted by E. coli bacteria to form an extracellular matrix that shi
 elds them from environmental factors in a biofilm setting\, this polymer w
 as named pEtN cellulose\, after its distinctive phosphoethanolamine side c
 hain. This discovery illuminated the fact that bacteria can make a modifie
 d cellulose with interesting functional consequences\, and it inspired us 
 to think of the pEtN modification specifically\, which is not listed among
  the plethora of artificial cellulose derivatives currently in the literat
 ure. The work presented describes the exploratory path in discovering the 
 pEtN side chain’s potential in the design and application of novel bioma
 terials. This includes synthesizing pEtN cellulose in a number of ways\, a
 nd also working on incorporating the pEtN side chain onto other polymeric 
 backbones. The specificity and nature of these newly designed polymers dep
 end on the goal to which the intended biomaterials are to be used\, and so
  possible future applications are very diverse. These range from food rela
 ted applications\, through pharmaceuticals and medical devices\, and all t
 he way to templates in genetically designed plants as alternative feed sou
 rces in bioethanol fuel production. Given the rich history of cellulosic m
 aterials\, it is fair to assume this naturally formed side chain will also
  be incorporated into many new and exciting research avenues.
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