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UID:950@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200810T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/developing-cell-derived-nano-gho
 st-for-targeted-combined-therapy-of-metastatic-cancer-2/
SUMMARY:Developing Cell-Derived Nano-Ghost for Targeted Combined Therapy of
  Metastatic Cancer
DESCRIPTION:Metastasis is the major cause of treatment failure and mortalit
 y. The main goal of this study was to develop a natural targeted delivery 
 platform—termed Nano-Ghosts that will target metastatic cancer while del
 ivering different therapeutics. The NGs are nano-vesicles reconstructed fr
 om the cytoplasmic membranes of allogeneic human mesenchymal stem cells (M
 SC). The NGs’ retention of MSC membrane proteins ensures their safety an
 d allogenic tolerability and furnishes them with the ability to home in on
  multiple tumors. I will first demonstrated that the NGs selectively accum
 ulated in the lungs of metastases-bearing mice. Next\, I will present that
  NG loaded with soluble TRAIL protein or a pDNA encoding the same protein 
 (pTRAIL) promoted apoptosis in metastatic cancer cells. Furthermore\, effi
 cacy studies in a metastatic NSCLC model demonstrated over 70% tumor growt
 h inhibition of established metastases\n\n \n\nAbstract
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