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UID:991@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210105T173000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/developing-optical-sensors-for-a
 pplications-in-biochemistry-and-cancer-research-2/
SUMMARY:Developing Optical Sensors for Applications in Biochemistry and Can
 cer Research
DESCRIPTION:Real time sensing of biological processes in diseases is critic
 al for many fields\, especially cancer. Optical sensors enable fast\, reli
 able\, and highly sensitive detection of various states. Among many materi
 als\, the physical and optical properties of single-walled carbon nanotube
 s (SWCNTs) set them apart as indispensable sensors and offer unique applic
 ations in biology\, biotechnology and medicine. During my postdoctoral wor
 k I have developed both in vitro and in vivo biosensors for detecting dise
 ases\, monitoring biological processes in both the micro and macro scale\,
  and integrating machine learning algorithms to create robust sensing plat
 forms. I engineered a sensor that tracks a specific enzymatic pathway that
  leads to irreversible enzyme inactivation. This sensor can be used to scr
 een novel molecules such as enzyme inhibitors. Furthermore\, I designed an
  array of biosensors to develop an optical platform for detection of multi
 ple ovarian cancer biomarker-based proteins without using a specific bindi
 ng moiety (such as an antibody or aptamer)\, but rather by harnessing mach
 ine learning technology. I trained models with several classification and 
 regression algorithms to predict biomarker presence and create a molecular
  perceptron technology. In addition\, I have developed a clinical implanta
 ble biosensor for early ovarian cancer detection. The biosensor is compris
 ed of an ovarian cancer biomarker antibody conjugated to DNA-wrapped SWCNT
 s. This technology has the potential to increase patient survival by rapid
 ly informing and improving patient diagnosis and treatment regimens. Integ
 rating my background in nanotechnology\, personalized medicine\, and optic
 al biosensors\, I plan to develop novel analytical and diagnostic platform
 s for early detection of inflammatory diseases.\n\n \n\nAbstract
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