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UID:1061@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20211027T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124718Z
URL:https://biotech.technion.ac.il/events/development-of-3d-extracellular-
 matrix-ecm-based-cell-carriers-as-a-potential-platform-for-regenerative-me
 dicine-2/
SUMMARY:Development of 3D extracellular matrix (ECM)-based cell carriers as
  a potential platform for regenerative medicine
DESCRIPTION:Cell-based therapy is currently the leading approach for the de
 velopment of regenerative medicine platforms. Nevertheless\, transplanted 
 cells are often susceptible to the shear forces involved in the transplant
 ation procedure and the change of microenvironment\, and therefore\, exhib
 it poor survival rates. The use of biomimetic delivery systems can also in
 crease cell survival and re-acclimating in the tissue. Due to its unique b
 ioactivity\, porcine extracellular matrix (pECM) ―the natural bed of cel
 ls in the different tissues―holds a great promise as a biomaterial for c
 ell-based therapies. To elaborate on the distinctive properties of pECM de
 rived from different tissues\, and their consequent ability to support cel
 ls\, we decellularized and solubilized different porcine tissues and produ
 ced thermally induced pECM hydrogels. The obtained hydrogels varied in com
 position\, structure\, and mechanical properties. Consequently\, the morph
 ology and viability of mesenchymal stem cells (MSCs)\, as well as the spon
 taneous differentiation of human induced pluripotent stem cells (hiPSCs)\,
  cultured on the hydrogels\, were considerably affected by the pECM origin
 . We have further produced spherical shape microscale carriers comprised s
 olely of the solubilized pECM for the cardiac tissue regeneration. Upon se
 eding MSCs\, these pECM-carriers supported cell viability and proliferatio
 n and supported hiPSCs viability and differentiation. To conclude\, pECM-b
 ased cell delivery systems benefit unique\, tissue-specific attributes tha
 t affect their properties\, interactions with their resident cells\, and g
 enerate a natural supportive bed for improved transplantation outcomes\n\n
  \n\nFull Abstract
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