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UID:1057@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210901T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124718Z
URL:https://biotech.technion.ac.il/events/development-of-novel-selectively
 -targeted-multifunctional-nanostructured-lipid-carriers-for-prostate-cance
 r-treatment-2/
SUMMARY:Development of novel selectively targeted multifunctional nanostruc
 tured lipid carriers for prostate cancer treatment
DESCRIPTION:Prostate cancer (PC) is the most common cancer in men over the 
 age of 50 and the 4th most prevalent human malignancy. The current modalit
 ies to treat PC include surgery\, radiation\, androgen deprivation therapy
  (ADT) and chemotherapy. The therapeutic efficacy of systemic drug treatme
 nt is limited due to low drug solubility and lack of tumor specificity inf
 licting toxic side effects\, and frequent emergence of drug-resistance. He
 rein we present selectively PC-targeted nanoparticles (NPs) harboring cyto
 toxic drugs cargo. The delivery system is based on PEGylated nanostructure
 d lipid carriers\, decorated with a selective peptide\, targeted to prosta
 te-specific membrane antigen (PSMA). NPs loaded with a chemotherapeutic dr
 ug\, displayed remarkable encapsulation capacity of 168±3 mg drug/gr shel
 l material\, encapsulation efficiency of 67±1%\, and an average diameter 
 of 148±4 nm. The kinetics of in vitro drug release from NPs showed a subs
 tantial drug retention profile compared to unencapsulated drug. These NPs 
 were selectively internalized into target PC cells overexpressing PSMA and
  displayed a dose-dependent cytotoxicity\, compared to cells lacking PSMA 
 receptor. This selectively targeted nano-delivery platform bear promise fo
 r achieving enhanced efficacy and minimization of untoward toxicity\, thus
  should improve patient survival rates and quality of life.
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