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UID:988@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20201230T160000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/dna-methylation-and-foxa-pioneer
 -factors-regulate-liver-stability-and-plasticity-2/
SUMMARY:DNA Methylation and FoxA Pioneer Factors Regulate Liver Stability a
 nd Plasticity
DESCRIPTION:Pioneer factors play a critical role in differentiation by gene
 rating chromatin accessibility and by activating enhancers. As differentia
 tion progress\, additional tissue-specific transcription factors bind thes
 e enhancers thus generating a stable and robust regulatory network that is
  thought to be resistant to the loss of any specific transcription factor.
  I found that pioneer factors are continuously guarding enhancer activity 
 throughout adult life thus maintaining tissue integrity. An exception to t
 his is DNA hypomethylation at these sites that are programmed by pioneer f
 actors in embryonic development and are not dependent on the continuous pr
 esence of pioneer factors in the adult tissue. These findings distinguish 
 between cellular components that enhance stability versus those that enabl
 e plasticity.\n\nAbstract
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