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UID:1047@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210707T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124718Z
URL:https://biotech.technion.ac.il/events/expression-and-characterization-
 of-proteins-for-drug-and-food-applications-2/
SUMMARY:Expression and characterization of proteins for drug and food appli
 cations
DESCRIPTION:Over the last few decades\, recombinant proteins have been prod
 uced for diverse applications. Antibodies are manufactured for immunothera
 py and diagnostic devices. A variety of enzymes are used to treat genetic 
 disorders\; while others are developed for industrial use like biodiesel p
 roduction. Recently\, recombinant proteins are also being developed for fo
 od applications\, some of which have recently been recognized as safe. Two
  recombinant proteins were expressed and characterized in this research in
  various expression systems (bacteria\, yeast\, insect and mammalian).\nTh
 e goal of the first project was to develop an enzymatic treatment to slowd
 own Alzheimer’s disease progression. An early characteristic of Alzheime
 r’s disease is formation of plaques\, which are neurotoxic aggregates of
  Amyloid ß peptides. Cleavage within the Amyloid ß peptide sequence\, ma
 y prevent formation of plaques and will therefore slowdown disease progres
 sion. To this end\, a specific protease was expressed in a variety of expr
 ession systems and the purified enzyme was characterized.\nThe goal of the
  second project was to uncouple potato patatin production from agriculture
 . In recent years there has been a growing interest in alternatives for an
 imal proteins\, to feed the world’s growing population. Protein alternat
 ives are divided to three categories: plant-based\, fermentation and cultu
 red meat. Of the plant-based proteins\, potato proteins provide an interes
 ting option due to their nutritional value and high functionality. However
 \, agriculture dependence\, cultivar variability and low yields may make t
 heir production challenging. Here\, two potato patatin isoforms were expre
 ssed in Pichia pastoris. Biochemical and physical characterization of the 
 purified recombinant proteins compared with commercial patatin\, revealed 
 that the purified yeast-derived patatins were comparable\, and in some cas
 es even superior\, to potato isolated patatins.\n\nAbstract
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