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UID:1049@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210714T180000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124718Z
URL:https://biotech.technion.ac.il/events/genomic-profile-of-thyroid-tumor
 s-occurring-after-the-chernobyl-nuclear-power-plant-accident-new-insights-
 into-radiation-carcinogenesis-2/
SUMMARY:Genomic profile of thyroid tumors occurring after the Chernobyl nuc
 lear power plant accident: new insights into radiation carcinogenesis
DESCRIPTION:The 1986 Chernobyl nuclear power plant accident increased papil
 lary thyroid cancer (PTC) incidence in surrounding regions\, particularly 
 for 131I-exposed children. We analyzed genomic\, transcriptomic\, and epig
 enomic characteristics of 440 PTCs from Ukraine (359 with estimated childh
 ood 131I exposure and 81 unexposed children born after 1986). PTCs display
 ed radiation dose-dependent enrichment of fusion drivers\, nearly all in t
 he mitogen-activated protein kinase pathway\, and increases in small delet
 ions and simple/balanced structural variants that were clonal and bore hal
 lmarks of non-homologous end-joining repair. Radiation-related genomic alt
 erations were more pronounced for those younger at exposure. Transcriptomi
 c and epigenomic features were strongly associated with driver events but 
 not radiation dose. Our results point to DNA double-strand breaks as early
  carcinogenic events that subsequently enable PTC growth following environ
 mental radiation exposure.\n\nAbstract
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