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UID:1031@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210512T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/harnessing-developmental-biology
 -to-cure-type-1-diabetes-2/
SUMMARY:Harnessing developmental biology to cure type 1 diabetes
DESCRIPTION:Type 1 diabetes (T1D) is a chronic debilitating disease caused 
 by an autoimmune attack that destroys the insulin-producing beta cells in 
 the pancreatic islets. Although islet transplantation from cadaveric donor
 s provides an effective\, years-long cure for the disease\, donor scarcity
  limits the treatment’s availability. In an attempt to overcome islet sc
 arcity\, several labs have recently developed protocols for the directed d
 ifferentiation of functional beta cells from pluripotent stem cells. In my
  talk\, I will present my efforts to improve these protocols and bring the
 m closer to the clinic by uncovering the basic mechanisms that direct cell
 ular differentiation and islet morphogenesis during embryonic development 
 of the pancreas. In addition\, I will show how the use of tools from the f
 ield of developmental biology\, combined with single cell RNA sequencing\,
  can serve to uncover the causes for the eruption of T1D and to outline it
 s progression.\n\n \n\nFull Abstract
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