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UID:1029@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210505T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/host-succinate-is-an-activation-
 signal-for-salmonella-virulence-during-intracellular-infection-2/
SUMMARY:Host succinate is an activation signal for Salmonella virulence dur
 ing intracellular infection
DESCRIPTION:Key to the success of intracellular pathogens is the ability to
  sense and respond to a changing host cell environment. Macrophages expose
 d to microbial products undergo metabolic changes that drive inflammatory 
 responses. However\, the role of macrophage metabolic reprogramming in bac
 terial adaptation to the intracellular environment has not been explored. 
 Here\, using metabolic profiling and dual RNA sequencing\, we show that su
 ccinate accumulation in macrophages is sensed by intracellular Salmonella 
 Typhimurium (S. Tm) to promote antimicrobial resistance and type III secre
 tion. S. Tm lacking the succinate uptake transporter DcuB displays impaire
 d survival in macrophages and in mice. Thus\, S. Tm co-opts the metabolic 
 reprogramming of infected macrophages as a signal that induces its own vir
 ulence and survival\, providing an additional perspective on metabolic hos
 t–pathogen cross-talk.\n\n \n\nAbstract
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DTSTART:20211031T010000
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