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UID:932@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200525T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/human-cytochrome-p450-enzymes-ap
 plications-and-perspectives-2/
SUMMARY:Human Cytochrome P450 Enzymes: Applications and Perspectives
DESCRIPTION:Human Cytochrome P450 Enzymes: Applications and Perspectives\n\
 nThe majority of drugs used in human patients are substrates of drug metab
 olizing enzymes\, which are classified into the two groups of Phase I and 
 Phase II enzymes depending on the type of reaction they catalyze: Phase I 
 is characterized by functionalization reactions (such as redox reactions)\
 , while in Phase II conjugation reactions occur (such as glucuronidation).
  The most important enzymes in Phase I metabolism are the cytochrome P450 
 enzymes (CYPs or P450s)\, which belong to a large superfamily of monooxyge
 nases present in all biological kingdoms. We have recently introduced the 
 use of permeabilized fission yeast cells (enzyme bags) that recombinantly 
 express full-length human CYPs for drug metabolism studies. Moreover\, a c
 omplete set of recombinant fission yeast strains that coexpress each of th
 e 57 human P450s together with its natural human electron transfer partner
 (s) was cloned. This strain collection was used to establish a convenient 
 testing scheme that permits a rapid screen of all human CYPs for activity 
 towards any given candidate substrate. Interesting applications of this te
 chnology include the study of the metabolism of the active pharmaceutical 
 ingredients of Chinese Medicines and the development of a CYP4Z1-dependent
  prodrug strategy for the treatment of breast cancer. In addition\, we hav
 e also extended the scope of our research to include other human drug meta
 bolizing enzymes (such as UDP glucuronosyl transferases) on one hand and P
 450s from other species (e.g. insect pests) on the other hand.\n\n \n\n 
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