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UID:958@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200914T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/identification-of-novel-type-iii
 -secretion-system-effectors-in-edwardsiella-anguillarum-et080813-2/
SUMMARY:Identification of novel type III secretion system effectors in Edwa
 rdsiella anguillarum ET080813
DESCRIPTION:Fish diseases are a major threat to the sustainability of the a
 quaculture industry globally. Edwardsiella species are common and importan
 t pathogens of freshwater and marine fish\, which lead to severe economic 
 losses in aquaculture worldwide. The Type III Secretion System (T3SS) is a
 n important weapon of these pathogens\, since it secretes virulence factor
 s (effector proteins) to assist the bacteria’s invasion and escape from 
 the host’s immune defense. However\, research on virulence mechanisms of
  Edwardsiella is still in the early stage\, especially in the newly identi
 fied species\, Edwardsiella anguillarum. We have hypothesized that E. angu
 illarum can secrete many novel effectors\, since it possesses two distinct
  T3SSs\, and our aim was to discover these effectors. Based on bioinformat
 ics analysis\, including machine learning and sequence homology\, our resu
 lts showed that more than 10 putative effectors are encoded in the genome 
 of the E. anguillarum type strain ET080813. A phosphorylated mutant of the
  global regulator\, EsrB\, was used to turn on T3SSs in vitro. Secretome a
 nd transcriptome analyses were further performed to compare differential e
 xpression and secretion of the bacterial proteins. Based on the results we
  have shortlisted 56 candidate effectors for further studied. Furthermore\
 , our invasion assay results indicated that E. anguillarum ET080813 is abl
 e to internalize and replicate within host cells. Further characterization
  of these T3SSs secreted effectors will benefit the development of new the
 rapeutic strategies for the treatment of Edwardsiella bacterial diseases.\
 n\n \n\nAbstract
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