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UID:1019@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210317T163000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/identifying-gene-expression-chan
 ges-governing-fear-conditioning-using-single-cell-transcriptomics-2/
SUMMARY:Identifying gene expression changes governing fear conditioning usi
 ng single-cell transcriptomics
DESCRIPTION:Memory is fundamental to the survival of all animals\, as it en
 ables them to adapt their behavior according to their experience\, thus\, 
 it is a central research field in neuroscience. Yet\, despite the progress
  achieved in recognizing molecular mechanisms that are involved in learnin
 g and memory in the brain\, we still lack complete understanding how a mem
 ory is formed. Specifically\, although changes in brain gene expression we
 re shown to be crucial for memory acquisition\, little is known about the 
 magnitude and distribution of such changes in a given neuronal network tha
 t is involved in a specific memory – and which specific cell types contr
 ibute to memory formation .\nOur study aimed to bridge this gap of knowled
 ge and to define the transcriptional changes involved in the formation of 
 fear conditioning learning in the amygdala region using single-cell transc
 riptomics. Based on full transcriptome profiling of thousands of individua
 l neurons we managed to define the cell types in the amygdala and classify
  them into functional and regional categories. In addition\, we have found
  two different cell types that putatively play a role in fear learning. Fi
 nally\, we have found the specific localization of those two cell types wi
 thin the amygdala region in the brain\, using fluorescence in-situ hybridi
 zation. This is an important step towards detailed mapping of the brain’
 s building blocks and their function.\n\nAbstract
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