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UID:952@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200907T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/immunotherapeutic-nano-ghosts-a-
 cell-free-nanometric-system-for-off-the-shelf-cancer-immunotherapy-2/
SUMMARY:Immunotherapeutic Nano-Ghosts: A cell-free Nanometric system for Of
 f-The-Shelf Cancer Immunotherapy
DESCRIPTION:Autologous cytotoxic T lymphocytes (CTLs) has the ability to ch
 ange the course of a pathology. Unfortunately\, in the face of widely vari
 able and adaptive tumors\, often presenting a highly immunosuppressive env
 ironment and MHC-restriction\, the possible use of CTLs is largely limited
  to a small number of patients and very few types of cancers. The main goa
 l of this study was to combine the safety and tumor-targeting capabilities
  of mesenchymal stem cells (MSCs) with the tumor-restrictive capacity of C
 TLs in an inanimate platform that can withstand limiting host influences. 
 The foundations for this combination are laid by a novel class of nano-ves
 icles (200 nm)\, termed immunotherapeutic-nano-ghosts (iNGs)\, equipped wi
 th membrane proteins from MSCs and exogenous ones inspired by CTLs. We use
 d different methods to reach our goal\, by fusion of NGs from different so
 urce cells and by manipulating the MSCs to express death ligands inspired 
 by CTLs. Our iNGs system exhibited lethal effect in vitro on cancer cells 
 and in vivo in human melanoma model where it inhibited tumor growth to the
  same levels as the free drug\, but with 6-orders of magnitude lower effec
 tor concentration.\n\nAbstract
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