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UID:1098@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20230111T140000
DTEND;TZID=Asia/Jerusalem:20230111T150000
DTSTAMP:20230403T073403Z
URL:https://biotech.technion.ac.il/events/kinetic-models-of-central-carbon
 -metabolism-an-important-tool-towards-the-design-of-efficient-cell-factori
 es/
SUMMARY:Kinetic Models of Central Carbon Metabolism - an Important Tool Tow
 ards the Design of Efficient Cell-Factories
DESCRIPTION:Cell-Factories are cells that are used for production. To guide
  the design of efficient cell-factories accurate computational models are 
 required. These models will help predict the effects of gene knockouts\, a
 ddition of metabolic pathways and changes in the growth conditions on cell
 ular metabolic pathways and thus on the production efficiency of desired m
 etabolites. To explore the central carbon metabolism of two commonly used 
 cell-factories\, Escherichia coli and Saccharomyces cerevisiae\, we built 
 kinetic models which consider kinetic mechanisms and enzyme regulations. T
 hen\, we used omics reference data (e.g.\, metabolomics and fluxomics) fro
 m a single steady-state time point to generate ensembles of the kinetic mo
 dels. After generating the models\, we calculated the kinetic parameters f
 or the Escherichia coli model and compared the calculated values to litera
 ture values. In addition\, we performed a metabolic control analysis (MCA)
  to estimate the level of control each enzyme has on the metabolic fluxes 
 inside the cell. The results demonstrate that computational kinetic models
  are a powerful tool for investigating the metabolic network inside cells.
  The kinetic parameters calculated for the Escherichia coli model are rela
 tively close to the literature values\, which indicates that the model cap
 tures well the kinetics of the enzymes. In addition\, the MCA enables the 
 investigation of the complex regulation of the central carbon metabolism a
 nd we can identify specific enzymes with high control over the metabolic f
 luxes. This ability is central for directing the design of cell-factories.
CATEGORIES:אירועים
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