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UID:936@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200617T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/microalgae-resourcization-from-c
 arbon-biofixation-to-blue-biotechnology-2/
SUMMARY:Microalgae resourcization: From carbon biofixation to blue biotechn
 ology
DESCRIPTION:Microalgae are one of the dominant groups of phytoplankton in o
 ceans and account for more than 50% of global primary production. They are
  regarded as one of the most promising platform assets for sustainable pro
 duction of petrochemical substitutes and bioactive compounds. However\, a 
 prerequisite to achieving this goal is to increase the solar-to-biomass co
 nversion efficiency of photosynthesis\, which remains less than 5% for mos
 t photosynthetic organisms. Photosynthesis plays a central role in enablin
 g a bioeconomy to become sustainable and feasible to human beings. To enha
 nce photosynthesis while alleviating CO2 emissions\, we first conducted ad
 aptive laboratory evolution in microalgae and then successfully provided t
 he means to evolve green microalgae and diatoms with enhanced photosynthet
 ic efficiency as well as increased carotenoids accumulation using designed
  LEDbased photobioreactors. We further developed and implemented a rapid a
 nd effective approach\, named as intracellular spectral recompositioning (
 ISR) of light\, which\, through absorption of excess blue light and its in
 tracellular emission in the green spectral band\, can improve light utiliz
 ation. We demonstrate that ISR-based eGFP transformants of the model diato
 m Phaeodactylum tricornutum could outperform their wild-type parental stra
 in by 50% in biomass production rate under simulated outdoor sunlight cond
 itions. We also identified key photosynthesis genes as well as major non p
 hotochemical quenching (NPQ) genes involved in light stress response\, whi
 ch may contribute to the enhancement of photosynthesis in engineered P. tr
 icornutum strains. Our findings demonstrate the feasibility of developing 
 more efficient photosynthetic cell factories to produce algae-based bioact
 ive compounds and biofuels while addressing global CO2 emission issues.\n\
 nMeeting ID: 945 5897 8222\nhttps://technion.zoom.us/j/94558978222
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