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UID:1055@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210728T173000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124718Z
URL:https://biotech.technion.ac.il/events/oligosaccharide-lactoferrin-conj
 ugates-particles-for-selective-targeting-of-proteins-to-probiotic-bacteria
 -in-the-colon-2/
SUMMARY:Oligosaccharide-Lactoferrin conjugates particles for selective targ
 eting of proteins to probiotic bacteria in the colon
DESCRIPTION:Consumption of prebiotic glycans seems to be a more effective a
 pproach to encourage the proliferation of gut probiotics\, for improving h
 ealth\, compared to consumption of live probiotic microorganisms. However\
 , these beneficial microorganisms require proteins to proliferate\, while 
 most consumed protein does not reach the gut. Still\, no protein-containin
 g prebiotics are commercially available. The main goal of this study was t
 o fabricate\, physicochemically characterize\, and evaluate the prebiotic 
 activity of a novel protein delivery system\, selectively-targeted to prob
 iotic bacteria in the colon. This system is composed of Maillard- conjugat
 es of prebiotic oligosaccharides and lactoferrin hydrolysate. Thorough phy
 sicochemical and digestibility characterization revealed that these conjug
 ates self-assemble into stable micelles\, exhibiting low digestibility and
  high potential to reach the colon. In-vivo study in mice established the 
 improved prebiotic activity of these conjugates\, showing a statistically 
 significant increase in the colonic concentration of short-chain-fatty-aci
 ds\, a beneficial metabolite produced by probiotics. Altogether\, this wor
 k holds great promise towards the development of the next generation of pr
 ebiotic compounds: protein-containing prebiotics.\n\n \n\nAbstract
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