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UID:956@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200909T173000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/rapid-antimicrobial-susceptibili
 ty-testing-of-clinical-samples-using-photonic-silicon-microarrays-2/
SUMMARY:Rapid Antimicrobial Susceptibility Testing of Clinical Samples usin
 g Photonic Silicon Microarrays
DESCRIPTION:The intensive and improper use of antibiotics has dramatically 
 increased the frequency of resistance among human pathogens and led to a g
 lobal crisis of antimicrobial resistance. Thus\, there is an urgent need t
 o develop rapid diagnostic methods. In this work\, we present a prototype 
 device for rapid antimicrobial susceptibility testing (AST) using photonic
  silicon chips which provide both a preferable solid-liquid interface for 
 bacteria networking and a simultaneous optical transducing element for mon
 itoring bacteria upon exposure to antibiotics in real-time. The latter is 
 achieved via intensity-based reflectometric interference spectroscopic mea
 surements\, referred to as iPRISM. First\, we determine the iPRISM breakpo
 int concentration for American Type Culture Collection strains using known
  standard breakpoints produced by the Clinical & Laboratory Standards Inst
 itute to differentiate between resistant and susceptible bacteria. Next\, 
 we demonstrate that iPRISM can robustly differentiate between resistant an
 d susceptible clinical isolates of Escherichia coli and Staphylococcus aur
 eus within 
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