Smart biomaterials, also termed stimuli responsive, react in a desirable manner to minor changes induced in their environment. The main goal of this study was to design and fabricate biocompatible polymeric systems with responsive properties for specific biomedical purposes. We focused on low melting temperature polymers and adjusted them to fit a clinical range. I will first present the contribution of these polymers to an NIR-light triggered system for drug delivery and self-healing applications. Next, I will demonstrate a new concept for bioadhesion facilitated by a controlled temperature glue gun. Following application, the polymers solidify at body temperature, create strong bonding with the tissues, and slowly degrade while facilitating wound healing.