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UID:1006@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20210210T160000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124719Z
URL:https://biotech.technion.ac.il/events/single-cell-omics-in-oligodendro
 glia-opening-doors-to-understand-multiple-sclerosis-2/
SUMMARY:Single-cell omics in oligodendroglia: opening doors to understand m
 ultiple sclerosis
DESCRIPTION:Single-cell omics have shaped our understanding of cellular het
 erogeneity. Oligodendroglial cells\, the myelinating cells of the central 
 nervous system\, were no exception. There are up to thirteen different oli
 godendroglial populations in the healthy central nervous system. What happ
 ens to these different populations in diseases such as multiple sclerosis 
 (MS)? Do they react or are affected differently? To answer these questions
  we have performed single cell/nucleus transcriptomic analysis of oligoden
 droglial cells from both human postmortem MS tissue\, and MS animal models
 . Excitingly\, we found that unique oligodendroglial populations emerge in
  response to disease. Of notice\, we uncovered a subset of oligodendrocyte
 s and their progenitor populations expressing genes involved in antigen pr
 ocessing and presentation implying alternative functions of these cells in
  a disease context. Our results suggest that oligodendroglial cells are no
 t passive targets but instead active immunomodulators in MS.\n\n \n\nFull
  Abstract
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