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UID:889@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20191218T160000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124721Z
URL:https://biotech.technion.ac.il/events/targeting-osteoarthritis-with-na
 no-ghost-system-entrapping-rna-interference-molecules-2/
SUMMARY:Targeting osteoarthritis with Nano-Ghost system entrapping RNA inte
 rference molecules
DESCRIPTION:Osteoarthritis (OA) is a leading cause of joint disability worl
 dwide\, characterized by articular cartilage degradation\, synovial inflam
 mation and bone remodeling\, with no disease-modifying treatments availabl
 e. In recent years\, RNA interference (RNAi) therapy has shown great poten
 tial\, but the clinical translation is largely hindered by the lack of saf
 e delivery systems. Recently\, our lab has developed an innovative drug de
 livery platform\, termed Nano-Ghosts (NGs)\, consisting of nano-vesicles r
 econstructed from the plasma membrane of mesenchymal stem cells (MSCs). Th
 e NGs retain MSCs’ surface features and targeting capabilities towards i
 nflammation sites. This homing process is regulated by composition\, orien
 tation\, and functions associated with MSCs’ membrane. NGs lack all the 
 internal machinery of a cell\, therefore they do not respond to external s
 timuli and they are not susceptible to host-induced changes. This study ai
 med to establish NGs as a new delivery platform for therapeutic antisense 
 oligonucleotides for OA treatment. NGs were produced and characterized as 
 previously published. The retention of the MSCs’ markers and the NGs cap
 ability of targeting different cells within the joint compartment (in vitr
 o\, ex vivo and in vivo) were demonstrated. Different approaches to load c
 argoes were studied and the characterization of the NGs after the loading 
 was performed. Biological studies were performed to assess the delivery of
  oligonucleotides by NGs\, and their ability to silence their targets to e
 xert therapeutic functions. NGs showed high efficiency in delivering the l
 oaded cargoes\, and the oligonucleotides exhibited strong silencing action
 s. In conclusion\, we developed a novel and effective NGs-based system for
  delivering different antisense oligonucleotides in the articular joint\, 
 demonstrating that the oligonucleotides exerted their functions of gene mo
 dulation once delivered. The results indicate that the NGs are a promising
  nano-carrier platform for antisense oligonucleotides therapy\, not limite
 d to OA\, but for several diseases because of the high versatility of this
  class of therapeutics.
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