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UID:1072@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20171122T160000
DTEND;TZID=Asia/Jerusalem:20220202T155700
DTSTAMP:20220512T124724Z
URL:https://biotech.technion.ac.il/events/the-plant-age-materials-for-the-
 future/
SUMMARY:The Plant Age\; Materials for the future
DESCRIPTION:Bringing together the toughness of cellulose nano-fibers from t
 he plant kingdom\, the remarkable elasticity and resilience of resilin tha
 t enables flees to jump as high as 100 times their height from the insect 
 kingdom combined with Human Recombinant Type I collagen produced in tobacc
 o plants\; These are the materials of the future\; Nature's Gift.  Resili
 n is a polymeric rubber-like protein secreted by insects to specialized cu
 ticle regions\, in areas where high resilience and low stiffness are requi
 red. Plant cell walls also present durable composite structures made of ce
 llulose\, other polysaccharides\, and structural proteins. Plant cell wall
  composite exhibit extraordinary strength exemplified by their ability to 
 carry the huge mass of some forest trees.  Inspired by the remarkable mec
 hanical properties of insect cuticle and plant cell walls we have develope
 d novel composite materials of resilin and Crystalline Nano-Cellulose (res
 iline-CNC) that display remarkable mechanical properties combining strengt
 h and elasticity. As a central element of the extracellular matrix\, colla
 gen is intimately involved in tissue development\, remodeling\, and repair
  and confers high tensile strength to tissues. Numerous medical applicatio
 ns\, particularly\, wound healing\, cell therapy\, and bone reconstruction
 \, rely on its supportive and healing qualities. Its synthesis and assembl
 y require a multitude of genes and post-translational modifications. Histo
 rically\, collagen was always extracted from animal and human cadaver sour
 ces\, but bare risk of contamination and allergenicity and was subjected t
 o harsh purification conditions resulting in irreversible modifications im
 peding its biofunctionality. A tobacco plant expression platform has been 
 recruited to effectively express human collagen\, along with three modifyi
 ng enzymes\, critical to collagen maturation. The plant extracted recombin
 ant human collagen type I forms thermally stable helical structures\, fibr
 illates\, and demonstrates bioactivity resembling that of native collagen.
  Today in greenhouses all over Israel farmers grow transgenic tobacco plan
 ts producing human recombinant collagen that is used for the production of
  medical implants that have already in clinical use. Combining collagen at
  the nano-scale with resilin to produce fibers resulted in super-performin
 g fibers with mechanical properties which exceed that of natural fibers. W
 e will demonstrate utility of hrCollagen\, Cellulose Nano Crystals and res
 ilin using Additive Manufacturing technologies ranging from micron to subm
 icron resolution using 2-photon printing technology.\n\n&nbsp\;
CATEGORIES:סמינרים
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