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UID:954@biotech.technion.ac.il
DTSTART;TZID=Asia/Jerusalem:20200909T170000
DTEND;TZID=Asia/Jerusalem:20220202T164952
DTSTAMP:20220512T124720Z
URL:https://biotech.technion.ac.il/events/the-role-of-the-iron-storage-pro
 tein-ferritin-in-iron-distribution-in-the-kidney-focusing-on-the-glomerulu
 s-2/
SUMMARY:The role of the iron storage protein Ferritin in iron distribution 
 in the kidney: Focusing on the Glomerulus
DESCRIPTION:The kidney plays a major role in systemic iron homeostasis\, as
  it controls the most iron consuming pathway of the body\, erythropoiesis.
  Nevertheless\, little is known on iron transport and its regulation in th
 e kidney. Ferritin\, the main intracellular iron storage protein\, is secr
 eted avidly and taken up by the human transferrin receptor 1. This led us 
 to hypothesize that ferritin may function as an iron transporter\, also in
  the kidney .To better understand iron homeostasis of the kidney\, we deci
 ded to focus first on the glomerulus\, and test if secretion and re-uptake
  of ferritin by specific glomerular cell types affects the iron distributi
 on between kidney-cells\, and how this may change cellular iron status. We
  isolate glomeruli from mouse-kidneys and grow primary cultures of podocyt
 es and mesangial cells\, for analysis of secretion and uptake of ferritin.
  To find the ferritin location in whole tissue\, we co-localize ferritin a
 nd glomerular cell-markers in kidney sections and isolated glomeruli. Foll
 owing iron injections\, the renal distribution of ferric iron is dynamic f
 or several days. In addition\, the two ferritin subunits H and L are distr
 ibuted differently across sections of iron-overloaded mice. The staining r
 esults suggested\, that glomerular endothelial cells contain very little f
 erritin\, while ferritin expression is more prominent in podocytes and mes
 angial cells. The ability to grow primary cultures of podocyte and mesangi
 al cells will be a useful tool to analyze their ferritin expression\, secr
 etion and uptake\n\n \n\nAbstract
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