The Laboratory of Biological Condensate Engineering

Asst. Prof. Dan Bracha

We are an interdisciplinary group of scientists studying intracellular liquid phase condensation and aggregation of intrinsically disordered proteins using novel bioengineered tools.

Our goal is to elucidate the cellular principles that govern these fundamental physicochemical transitions and underlie the assembly, function, and dysfunction of membraneless compartments/organelles, condensed assemblies that organize the cellular interior and coordinate complex cellular tasks, from transcription, genome organization, and ribosome biogenesis, to nucleocytoplasmic trafficking, RNA transport, and stress response.

Unraveling these principles and exploiting the intrinsic ability of cellular condensates to sense, integrate, and rapidly respond to environmental cues hold great promise for developing novel technological applications and may hold the key to unlocking some of the greatest unsolved mysteries of cellular homeostasis and pathogenesis.

 


Induced phase separation of the disordered, ALS-implicated protein FUS (left) and condensation of dense dsDNA (right).

Link to lab website: https://danbracha.weebly.com