Functionalized Microneedles for Tissue Sealing and Infection Control
Abstract: ** Lecture will be given in English**
Microneedle technology is widely recognized for its transdermal drug delivery applications; however, its engineering and medical potential extends far beyond that purpose. The current study presents the example of employing the same technological platform based on microneedle patches produced by micromolding process to solve entirely different medical problems: internal tissue sealing and localized infection control. First, a bio adhesive microneedle patch was designed as an internal surgical sealant, composed of crosslinked Polyacrylic acid needles and a Chitosan base. This patch offers a painless alternative to sutures, exhibiting high burst pressure resistance, establishing robust mechanical and chemical interlocking with wet, soft tissue surfaces for a leak-proof closure without secondary tissue damage. In another project, similar microneedle architecture was utilized for treating localized skin infection. These microneedles were molecularly functionalized by the conjugation with Polymyxin B. This distinct application focuses on the rapid, localized adsorption and neutralization of Lipopolysaccharides. This allows effectively preventing endotoxin-induced hyperinflammation and sepsis directly at the site. These two approaches demonstrate the remarkable adaptability of the microneedle platform, aiming to revolutionize biomaterial design and address unmet multifunctional needs.
