Engineered Supramolecular Nanostructures for Tissue Regeneration
** Lecture will be given in English**
Abstract:
Advances in regenerative medicine require materials that enable precise control over nanoscale organization, mechanical properties, and biological function. Our work focuses on bioinspired supramolecular scaffolds based on short aromatic peptides that undergo solvent-regulated self-assembly and polymorphic phase transitions. This approach allows fine-tuning of crystalline structure, stiffness, and bioactivity.
Co-assembly of complementary dipeptides yields exceptionally rigid hydrogels that promote cell mechanotransduction and osteogenic differentiation. Integration with biopolymers, such as hyaluronic acid and gelatin, yields injectable, 3D-printable composite hydrogels with thixotropic behavior and enhanced calcium mineralization, resulting in significant bone regeneration in vivo. To expand their functionality, we fabricate patient-specific, bioactive titanium implants via additive manufacturing and incorporate bioactive scaffolds to enhance their performance in bone rehabilitation following tumor resection .
In addition, we design conductive peptide-MXene hybrid hydrogels that function as piezoresistive sensors for real-time tissue monitoring and electrical stimulation. Furthermore, we developed an autologous electrospun polymer-peptide skin equivalent for the treatment of severe burn injuries, demonstrating accelerated wound closure and a reduction of T₅₀ from 12 to 4 days.
Together, these studies establish a modular platform that integrates mechanical tunability, printability, and sensing capabilities, enabling the design of multifunctional biomaterials and hybrid bioelectronic interfaces. This supramolecular strategy offers a versatile route toward personalized regenerative systems with strong translational potential across both soft and hard tissue repair .
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